Arnold Bayer

Professor Arnold Bayer, MD, FACP, FCCP, FIDSA.

David Geffen School of Medicine at UCLA; Los Angeles, CA;

Senior Investigator – LA Biomedical Research Institute at Harbor-UCLA

(310)-222-6422 (office)

(310)-809-0273 (mobile)

 

My labs focuses on bacterial pathogenesis, with a particular emphasis on pathogens causing vascular infections (e.g.,endocarditis). This includes Staph. aureus, enterococci and viridans group streptococci. We specifically study the adaptations these pathogens undergo at a cellular level to avoid innate host defenses, focusing on cationic antimicrobial peptides from white blood cells and platelets, as well as cationic clinical antimicrobials such as daptomycin and vancomycin (as in this proposal). My lab has devoted the last 20 years to studying the mechanisms by which the staphylococci and enterococci develop adaptive resistance to host defense peptides, and the last 6 years dovetailing those mechanistic investigations with those related to daptomycin-resistance. In two of my current Federal grants (NIH and DOD), I also serve as subcontract PI on several key MRSA projects via NIH.

Arnold Bayer

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